Download High throughput screening methods: evolution and refinement by Joshua A Bittker, Nathan T Ross, Tom Brown, Kira J Weissman, PDF

By Joshua A Bittker, Nathan T Ross, Tom Brown, Kira J Weissman, Claes Andersson, Douglas Auld, Peizin Zhu, Visit Amazon's Sean Ekins Page, search results, Learn about Author Central, Sean Ekins, , Jaime Cheah, Mark Wigglesworth, Damien Young, Michael Mesleh,

High throughput screening is still a key a part of early level drug and gear compound discovery, and strategies and applied sciences have obvious many basic advancements and thoughts over the last two decades. This entire ebook offers a ancient survey of the sector as much as the present state of the art. as well as the categorical tools, this e-book additionally considers cultural and organizational questions that characterize possibilities for destiny success.
Following thought-provoking foreword and creation from Professor Stuart Schreiber and the editors, chapters from top specialists throughout academia and hide preliminary concerns for screening, equipment acceptable for various targets in small molecule discovery, more moderen applied sciences that supply replacement ways to conventional miniaturization strategies, and sensible facets corresponding to rate and resourcing. in the context in their old improvement, authors clarify universal pitfalls and their solutions.
This ebook will function either a pragmatic reference and a considerate consultant to the philosophy underlying technological switch in any such fast-moving quarter for postgraduates and researchers in academia and undefined, fairly within the parts of chemical biology, pharmacology, structural biology and assay development.

Show description

Read Online or Download High throughput screening methods: evolution and refinement PDF

Best industrial & technical books

Industrial Solvents Handbook, 5th Ed., Fifth Edition

Thoroughly revised, and enormously elevated, this 5th version is a well-established and winning reference quantity designed mostly for the chemical and different procedure industries, yet should be came across invaluable through an individual desiring the newest pertinent facts on commercial solvents. This 5th version is uniquely precious while it turns into essential to pick out a brand new solvent on a aggressive or comparative foundation; while the accepted solvent, hired hitherto, could not be on hand, or can now not be used due to environmental purposes; or whilst costs have risen to such an volume that an current approach needs to be redesigned to make it economically possible back.

Enantioselective Homogeneous Supported Catalysis

Content material: Ionically-tagged transition-metal catalysts; Catalysis with supported organocatalysts; Supported ionic liquid section catalysis; Metal-catalysts on soluble polymers; Catalytic dendrimers; Fluorous catalysts and chiral auxiliaries in biphasic and homogeneous platforms; Aqueous-phase uneven catalysis; Non-covalent immobilization

Ionic Liquids: Science and Applications

Content material: PREFACE ; 1. IONIC LIQUID FUELS FOR CHEMICAL PROPULSION ; STEFAN SCHNEIDER, TOM HAWKINS, YONIS AHMED, STEPHAN DEPLAZES, AND JEFF turbines ; 2. IONIC drinks IN ELECTROSPRAY PROPULSION structures ; BENJAMIN D. PRINCE, BRUCE A. FRITZ, AND YU-HUI CHIU ; three. DECOMPOSITION AND COMBUSTION OF IONIC LIQUID COMPOUND SYNTHESIZED ; FROM N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE AND NITRIC ACID ; SHIQING WANG AND STEFAN T.

Additional info for High throughput screening methods: evolution and refinement

Sample text

F. Lovering, J. Bikker and C. Humblet, J. Med. , 2009, 52, 6752. 23. C. A. Lipinski, F. Lombardo, B. W. Dominy and P. J. Feeney, Adv. , 2001, 46, 3. 24. Parent and analogs were found using the ZINC database, http://zinc. org, (accessed May, 2016). 25. J. B. Baell, J. Chem. Inf. , 2013, 53, 39. 26. S. Fletcher and A. D. Hamilton, J. R. , Interface, 2006, 3, 215. 27. M. R. Arkin and J. A. Wells, Nat. Rev. Drug Discovery, 2004, 3, 301. 28. D. J. Payne, M. N. Gwynn, D. J. Holmes and D. L. Pompliano, Nat.

E. Shamu and K. Guy, Nat. Chem. , 2007, 3, 438. 3. J. Eder, R. Sdrani and C. Wiesmann, Nat. Rev. Drug Discovery, 2014, 13, 577. 4. A. J. Moura Barbosa and A. Del Rio, Curr. Top. Med. , 2012, 12, 866. 5. C. J. Harris, R. D. Hill, D. W. Sheppard, M. J. Slater and P. F. W. Stouten, Comb. Chem. High Throughput Screening, 2011, 14, 521–531. 6. V. Krchnak and M. Lebl, Mol. Diversity, 1996, 1, 193. 1039/9781782626770-00016 Considerations Related to Small-molecule Screening Collections 35 7. Y. C. Martin, J.

24. Parent and analogs were found using the ZINC database, http://zinc. org, (accessed May, 2016). 25. J. B. Baell, J. Chem. Inf. , 2013, 53, 39. 26. S. Fletcher and A. D. Hamilton, J. R. , Interface, 2006, 3, 215. 27. M. R. Arkin and J. A. Wells, Nat. Rev. Drug Discovery, 2004, 3, 301. 28. D. J. Payne, M. N. Gwynn, D. J. Holmes and D. L. Pompliano, Nat. Rev. Drug Discovery, 2007, 6, 29–40. 29. S. L. Schreiber, Science, 2000, 287, 1964. 30. L. A. Marcaurelle, E. Comer, S. Dandapani, J. R. Duvall, B.

Download PDF sample

Rated 4.78 of 5 – based on 9 votes