By Michael Torbenson MD
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Extra resources for Biopsy Interpretation of the Liver
1990;82(3):209,213,217–218. 65. Torbenson M, Hart J, Westerhoff M, et al. Neonatal giant cell hepatitis: histological and etiological findings. Am J Surg Pathol. 2010;34(10):1498–1503. 66. Devaney K, Goodman ZD, Ishak KG. Postinfantile giant-cell transformation in hepatitis. Hepatology. 1992;16(2):327–333. 67. Moreno-Otero R, Trapero-Marugán M, García-Buey L, et al. Drug-induced postinfantile giant cell hepatitis. Hepatology. 2010;52(6):2245–2246. 68. Fraquelli M, Colli A, Cocciolo M, et al. Adult syncytial giant cell chronic hepatitis due to herbal remedy.
The Knodell score gave numbers for the amount of inflammation in the portal tracts, the interface (or piecemeal necrosis, which included bridging necrosis and panacinar necrosis), the hepatic lobules, and fibrosis. 1 This paper revolutionized the study of chronic viral hepatitis because it allowed statistical analysis of biopsy data and provided potential endpoints in clinical studies. However, it was soon realized that combining fibrosis and inflammation into a single system was not optimal, and a number of subsequent fibrosis staging systems were quickly proposed over the next several years, including the Scheuer system, the Batts and Ludwig system, the Ishak system, and the Metavir system.
1996;44(6):590–594. 112. Ramakrishna B, Date A, Kirubakaran C, et al. Atypical copper cirrhosis in Indian children. Ann Trop Paediatr. 1995;15(3):237–242. 113. Nakanuma Y, Tsuneyama K, Ohbu M, et al. Pathology and pathogenesis of idiopathic portal hypertension with an emphasis on the liver. Pathol Res Pract. 2001;197(2):65–76. 114. Bosma A, Meuwissen SG, Stricker BH, et al. Massive pericellular collagen deposition in the liver of a young female with severe Crohn’s disease. Histopathology. 1989;14(1):81–90.