By Victor R. Preedy, Ross J. Hunter
Adipokines (also referred to as adipocytokines) are a gaggle of peptides secreted via adipose tissue. they've got varied roles, from services within the person cellphone to the total physique. This quantity examines quite a lot of particular adipokines in addition to their common mobile features, together with thermal tension and adipokine expression, significant frightened procedure roles for adiponectin in neuroendocrine and autonomic functionality, and astroglial leptin receptors. It discusses comparable ailments and prerequisites similar to nonalcoholic fatty liver disorder, metabolic syndrome, center and rheumatic ailments, and bronchial asthma and sleep issues.
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Extra info for Adipokines
Et al. 1997. Retinoic acid blocks adipogenesis by inhibiting C/EBPbetamediated transcription. Mol. Cell. Biol. 17: 1552-1561. H. et al. 2003. Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor. J. Biol. Chem. 278: 46107-46116. D. and K. Cianflone. 1994. The adipsin-ASP pathway and regulation of adipocyte function. Ann. Med. 26: 388-393. M. et al. 1983. Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiationdependent proteins during adipocyte development.
Obesity is a condition of volume expansion and sodium retention, and there is accumulating evidence for the activation of circulating and adipose RAAS. The significance of adipose angiotensinogen was illustrated by gain/loss of function in animals as well as in weight reduction studies, shedding light on the possible role of adipose angiotensinogen in obesity-associated hypertension. ANGIOTENSINOGEN EXPRESSION AND ITS REGULATION IN ADIPOCYTES Although the liver is the primary site of angiotensinogen production, angiotensinogen mRNA expression in adipocytes is comparatively high (68% of that in the liver).
2003. Adrenomedullin upregulates M2-muscarinic receptors in cardiomyocytes from P19 cell line. Br. J. Pharmacol. 139: 1219-27. Er, H. and S. Doğanay, E. Ozerol, and M. Yürekli. 2005. Adrenomedullin and leptin levels in diabetic retinopathy and retinal diseases. Ophthalmologica 219: 107-111. Fukai, N. and T. Yoshimoto, T. Sugiyama, and N. Ozawa. 2004. Concomitant expression of adrenomedullin and its receptor components in rat adipose tissues. Am. J. Physiol. Endocrinol. Metab. 288: E56-E62. Harmancey, R.